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Fortelny, N., Farlik, M., Fife, V., Gorki, A. D., Lassnig, C., Maurer, B., Meissl, K., Dolezal, M., Boccuni, L., Ravi Sundar Jose Geetha, A., Akagha, M. J., Karjalainen, A., Shoebridge, S., Farhat, A., Mann, U., Jain, R., Tikoo, S., Zila, N., Esser-Skala, W., Krausgruber, T., Sitnik, K., Penz, T., Hladik, A., Suske, T., Zahalka, S., Senekowitsch, M., Barreca, D., Halbritter, F., Macho-Maschler, S., Weninger, W., Neubauer, H. A., Moriggl, R., Knapp, S., Sexl, V., Strobl, B., Decker, T., Müller, M. & Bock, C. JAK-STAT signaling maintains homeostasis in T cells and macrophages. Nat Immunol 25, 847-859 (2024). https://doi.org/10.1038/s41590-024-01804-1

Woess, K., Macho-Maschler, S., Van Ingen Schenau, D. S., Butler, M., Lassnig, C., Valcanover, D., Poelzl, A., Meissl, K., Maurer, B., Brandstoetter, T., Vogl, C., Koren, A., Kubicek, S., Orlova, A., Moriggl, R., Strobl, B., Sexl, V., Van Leeuwen, F. N., Kuiper, R. P. & Mueller, M. Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade. Haematologica 108, 993-1005 (2023). https://doi.org/10.3324/haematol.2021.279848

Sukhbaatar, N., Schöller, M., Fritsch, S. D., Linke, M., Horer, S., Träger, M., Mazić, M., Forisch, S., Gonzales, K., Kahler, J. P., Binder, C., Lassnig, C., Strobl, B., Müller, M., Scheiber-Mojdehkar, B., Gundacker, C., Dabsch, S., Kain, R., Hengstschläger, M., Verhelst, S. H. L., Weiss, G., Theurl, I. & Weichhart, T. Duodenal macrophages control dietary iron absorption via local degradation of transferrin. Blood 141, 2878-2890 (2023). https://doi.org/10.1182/blood.2022016632

Granucci, F., Marongiu, L. & Strobl, B. Editorial: Women in molecular innate immunity. Front Immunol 14, 1234710 (2023). https://doi.org/10.3389/fimmu.2023.1234710

Zahalka, S., Starkl, P., Watzenboeck, M. L., Farhat, A., Radhouani, M., Deckert, F., Hladik, A., Lakovits, K., Oberndorfer, F., Lassnig, C., Strobl, B., Klavins, K., Matsushita, M., Sanin, D. E., Grzes, K. M., Pearce, E. J., Gorki, A. D. & Knapp, S. Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling. Mucosal Immunol 15, 896-907 (2022). https://doi.org/10.1038/s41385-022-00528-5

Moritsch, S., Mödl, B., Scharf, I., Janker, L., Zwolanek, D., Timelthaler, G., Casanova, E., Sibilia, M., Mohr, T., Kenner, L., Herndler-Brandstetter, D., Gerner, C., Müller, M., Strobl, B. & Eferl, R. Tyk2 is a tumor suppressor in colorectal cancer. Oncoimmunology 11, 2127271 (2022). https://doi.org/10.1080/2162402x.2022.2127271

Watzenboeck, M. L., Drobits, B., Zahalka, S., Gorki, A. D., Farhat, A., Quattrone, F., Hladik, A., Lakovits, K., Richard, G. M., Lederer, T., Strobl, B., Versteeg, G. A., Boon, L., Starkl, P. & Knapp, S. Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner. PLoS Pathog 17, e1009487 (2021). https://doi.org/10.1371/journal.ppat.1009487

Schroeder, J. H., Roberts, L. B., Meissl, K., Lo, J. W., Hromadova, D., Hayes, K., Zabinski, T., Read, E., Moreira Heliodoro, C., Reis, R., Howard, J. K., Grencis, R. K., Neves, J. F., Strobl, B. & Lord, G. M. Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid Cells In Vivo. Front Immunol 12, 760198 (2021). https://doi.org/10.3389/fimmu.2021.760198

Schnepf, D., Crotta, S., Thamamongood, T., Stanifer, M., Polcik, L., Ohnemus, A., Vier, J., Jakob, C., Llorian, M., Gad, H. H., Hartmann, R., Strobl, B., Kirschnek, S., Boulant, S., Schwemmle, M., Wack, A. & Staeheli, P. Selective Janus kinase inhibition preserves interferon-lambda-mediated antiviral responses. Sci Immunol 6 (2021). https://doi.org/10.1126/sciimmunol.abd5318

Poelzl, A., Lassnig, C., Tangermann, S., Hromadova, D., Reichart, U., Gawish, R., Mueller, K., Moriggl, R., Linkermann, A., Glosmann, M., Kenner, L., Mueller, M. & Strobl, B. TYK2 licenses non-canonical inflammasome activation during endotoxemia. Cell Death Differ 28, 748-763 (2021). https://doi.org/10.1038/s41418-020-00621-x

Pezoldt, J., Wiechers, C., Erhard, F., Rand, U., Bulat, T., Beckstette, M., Brendolan, A., Huehn, J., Kalinke, U., Mueller, M., Strobl, B., Deplancke, B., Cicin-Sain, L. & Sitnik, K. M. Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection. Commun Biol 4, 1355 (2021). https://doi.org/10.1038/s42003-021-02882-9

Hromadova, D., Elewaut, D., Inman, R. D., Strobl, B. & Gracey, E. From Science to Success? Targeting Tyrosine Kinase 2 in Spondyloarthritis and Related Chronic Inflammatory Diseases. Front Genet 12, 685280 (2021). https://doi.org/10.3389/fgene.2021.685280

Dichtl, S., Lindenthal, L., Zeitler, L., Behnke, K., Schlosser, D., Strobl, B., Scheller, J., El Kasmi, K. C. & Murray, P. J. Lactate and IL6 define separable paths of inflammatory metabolic adaptation. Sci Adv 7 (2021). https://doi.org/10.1126/sciadv.abg3505

De Vries, L. C. S., Ghiboub, M., van Hamersveld, P. H. P., Welting, O., Verseijden, C., Bell, M. J., Rioja, I., Prinjha, R. K., Koelink, P. J., Strobl, B., Muller, M., D'Haens, G. R., Wildenberg, M. E. & De Jonge, W. J. Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis. J Crohns Colitis 15, 617-630 (2021). https://doi.org/10.1093/ecco-jcc/jjaa199

Schroeder, J. H., Meissl, K., Hromadova, D., Lo, J. W., Neves, J. F., Howard, J. K., Helmby, H., Powell, N., Strobl, B. & Lord, G. M. T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells. Front Immunol 11, 623324 (2020). https://doi.org/10.3389/fimmu.2020.623324

Roewe, J., Stavrides, G., Strueve, M., Sharma, A., Marini, F., Mann, A., Smith, S. A., Kaya, Z., Strobl, B., Mueller, M., Reinhardt, C., Morrissey, J. H. & Bosmann, M. Bacterial polyphosphates interfere with the innate host defense to infection. Nat Commun 11, 4035 (2020). https://doi.org/10.1038/s41467-020-17639-x

Riedelberger, M., Penninger, P., Tscherner, M., Seifert, M., Jenull, S., Brunnhofer, C., Scheidl, B., Tsymala, I., Bourgeois, C., Petryshyn, A., Glaser, W., Limbeck, A., Strobl, B., Weiss, G. & Kuchler, K. Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection. Cell Host Microbe 27, 454-466 e458 (2020). https://doi.org/10.1016/j.chom.2020.01.023

Preglej, T., Hamminger, P., Luu, M., Bulat, T., Andersen, L., Goschl, L., Stolz, V., Rica, R., Sandner, L., Waltenberger, D., Tschismarov, R., Faux, T., Boenke, T., Laiho, A., Elo, L. L., Sakaguchi, S., Steiner, G., Decker, T., Bohle, B., Visekruna, A., Bock, C., Strobl, B., Seiser, C., Boucheron, N. & Ellmeier, W. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. JCI Insight 5 (2020). https://doi.org/10.1172/jci.insight.133393

Pflugler, S., Svinka, J., Scharf, I., Crncec, I., Filipits, M., Charoentong, P., Tschurtschenthaler, M., Kenner, L., Awad, M., Stift, J., Schernthanner, M., Bischl, R., Herndler-Brandstetter, D., Glitzner, E., Moll, H. P., Casanova, E., Timelthaler, G., Sibilia, M., Gnant, M., Lax, S., Thaler, J., Muller, M., Strobl, B., Mohr, T., Kaser, A., Trajanoski, Z., Heller, G. & Eferl, R. IDO1(+) Paneth cells promote immune escape of colorectal cancer. Commun Biol 3, 252 (2020). https://doi.org/10.1038/s42003-020-0989-y

Meissl, K., Simonovic, N., Amenitsch, L., Witalisz-Siepracka, A., Klein, K., Lassnig, C., Puga, A., Vogl, C., Poelzl, A., Bosmann, M., Dohnal, A., Sexl, V., Muller, M. & Strobl, B. STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity. Front Immunol 11, 2189 (2020). https://doi.org/10.3389/fimmu.2020.02189

Karjalainen, A., Shoebridge, S., Krunic, M., Simonovic, N., Tebb, G., Macho-Maschler, S., Strobl, B. & Muller, M. TYK2 in Tumor Immunosurveillance. Cancers (Basel) 12 (2020). https://doi.org/10.3390/cancers12010150

Gracey, E., Hromadova, D., Lim, M., Qaiyum, Z., Zeng, M., Yao, Y., Srinath, A., Baglaenko, Y., Yeremenko, N., Westlin, W., Masse, C., Muller, M., Strobl, B., Miao, W. & Inman, R. D. TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis. J Clin Invest 130, 1863-1878 (2020). https://doi.org/10.1172/JCI126567

Woss, K., Simonovic, N., Strobl, B., Macho-Maschler, S. & Muller, M. TYK2: An Upstream Kinase of STATs in Cancer. Cancers (Basel) 11 (2019). https://doi.org/10.3390/cancers11111728

Simonovic, N., Witalisz-Siepracka, A., Meissl, K., Lassnig, C., Reichart, U., Kolbe, T., Farlik, M., Bock, C., Sexl, V., Muller, M. & Strobl, B. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol 202, 1724-1734 (2019). https://doi.org/10.4049/jimmunol.1701649

Prutsch, N., Gurnhofer, E., Suske, T., Liang, H. C., Schlederer, M., Roos, S., Wu, L. C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D. A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Sternberg, C., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jäger, U., Staber, P. B., Grebien, F., Moriggl, R., Müller, M., Inghirami, G. G., Sanda, T., Look, A. T., Turner, S. D., Kenner, L. & Merkel, O. Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia 33, 696-709 (2019). https://doi.org/10.1038/s41375-018-0239-1

Kollmann, S., Grundschober, E., Maurer, B., Warsch, W., Grausenburger, R., Edlinger, L., Huuhtanen, J., Lagger, S., Hennighausen, L., Valent, P., Decker, T., Strobl, B., Mueller, M., Mustjoki, S., Hoelbl-Kovacic, A. & Sexl, V. Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia. Leukemia 33, 1583-1597 (2019). https://doi.org/10.1038/s41375-018-0369-5

Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago-Horvath, Z., Macho-Maschler, S., Poelzl, A., Simonovic, N., Prchal-Murphy, M., Rom, R., Amenitsch, L., Ferrarese, L., Kornhoff, J., Lederer, T., Svinka, J., Eferl, R., Bosmann, M., Kalinke, U., Stoiber, D., Sexl, V., Krmpotic, A., Jonjic, S., Muller, M. & Strobl, B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep 26, 2394-2406 e2395 (2019). https://doi.org/10.1016/j.celrep.2019.02.017

Dantoft, W., Robertson, K. A., Watkins, W. J., Strobl, B. & Ghazal, P. Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade. Front Microbiol 10, 355 (2019). https://doi.org/10.3389/fmicb.2019.00355

Porpaczy, E., Tripolt, S., Hoelbl-Kovacic, A., Gisslinger, B., Bago-Horvath, Z., Casanova-Hevia, E., Clappier, E., Decker, T., Fajmann, S., Fux, D. A., Greiner, G., Gueltekin, S., Heller, G., Herkner, H., Hoermann, G., Kiladjian, J. J., Kolbe, T., Kornauth, C., Krauth, M. T., Kralovics, R., Muellauer, L., Mueller, M., Prchal-Murphy, M., Putz, E. M., Raffoux, E., Schiefer, A. I., Schmetterer, K., Schneckenleithner, C., Simonitsch-Klupp, I., Skrabs, C., Sperr, W. R., Staber, P. B., Strobl, B., Valent, P., Jaeger, U., Gisslinger, H. & Sexl, V. Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy. Blood 132, 694-706 (2018). https://doi.org/10.1182/blood-2017-10-810739

Parrini, M., Meissl, K., Ola, M. J., Lederer, T., Puga, A., Wienerroither, S., Kovarik, P., Decker, T., Müller, M. & Strobl, B. The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment. Front Immunol 9, 2879 (2018). https://doi.org/10.3389/fimmu.2018.02879

Crnčec, I., Modak, M., Gordziel, C., Svinka, J., Scharf, I., Moritsch, S., Pathria, P., Schlederer, M., Kenner, L., Timelthaler, G., Müller, M., Strobl, B., Casanova, E., Bayer, E., Mohr, T., Stöckl, J., Friedrich, K. & Eferl, R. STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer. Mol Oncol 12, 514-528 (2018). https://doi.org/10.1002/1878-0261.12178

Raje, V., Derecka, M., Cantwell, M., Meier, J., Szczepanek, K., Sisler, J. D., Strobl, B., Gamero, A., Harris, T. E. & Larner, A. C. Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells. Endocrinology 158, 148-157 (2017). https://doi.org/10.1210/en.2015-2048

Meissl, K., Macho-Maschler, S., Müller, M. & Strobl, B. The good and the bad faces of STAT1 in solid tumours. Cytokine 89, 12-20 (2017). https://doi.org/10.1016/j.cyto.2015.11.011

Maier, B. B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral, J. B., Mesteri, I., Strobl, B., Müller, M., Kalinke, U., Merad, M. & Knapp, S. Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. Eur J Immunol 46, 2175-2186 (2016). https://doi.org/10.1002/eji.201546201

Gotthardt, D., Putz, E. M., Grundschober, E., Prchal-Murphy, M., Straka, E., Kudweis, P., Heller, G., Bago-Horvath, Z., Witalisz-Siepracka, A., Cumaraswamy, A. A., Gunning, P. T., Strobl, B., Müller, M., Moriggl, R., Stockmann, C. & Sexl, V. STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion. Cancer Discov 6, 414-429 (2016). https://doi.org/10.1158/2159-8290.Cd-15-0732

Floss, D. M., Klöcker, T., Schröder, J., Lamertz, L., Mrotzek, S., Strobl, B., Hermanns, H. & Scheller, J. Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases. Mol Biol Cell 27, 2301-2316 (2016). https://doi.org/10.1091/mbc.E14-12-1645

Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Damböck, U., Kröger, A., Weiss, S., Knapp, S., Jamieson, A. M., Kirschning, C., Kalinke, U., Strobl, B., Müller, M., Stoiber, D., Lienenklaus, S. & Kovarik, P. Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19, 375-387 (2016). https://doi.org/10.1016/j.chom.2016.02.003