Wiesauer, I., Gaumannmüller, C., Steinparzer, I., Strobl, B. & Kovarik, P. Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol 35, 716-727 (2015). https://doi.org/10.1128/mcb.01097-14

Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Kenner, L., Müller, M. & Decker, T. Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons. Mol Cell Biol 35, 2332-2343 (2015). https://doi.org/10.1128/mcb.01498-14

Pathria, P., Gotthardt, D., Prchal-Murphy, M., Putz, E. M., Holcmann, M., Schlederer, M., Grabner, B., Crncec, I., Svinka, J., Musteanu, M., Hoffmann, T., Filipits, M., Berger, W., Poli, V., Kenner, L., Bilban, M., Casanova, E., Müller, M., Strobl, B., Bayer, E., Mohr, T., Sexl, V. & Eferl, R. Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. Oncoimmunology 4, e998529 (2015). https://doi.org/10.1080/2162402x.2014.998529

Hainzl, E., Stockinger, S., Rauch, I., Heider, S., Berry, D., Lassnig, C., Schwab, C., Rosebrock, F., Milinovich, G., Schlederer, M., Wagner, M., Schleper, C., Loy, A., Urich, T., Kenner, L., Han, X., Decker, T., Strobl, B. & Müller, M. Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. J Immunol 195, 5011-5024 (2015). https://doi.org/10.4049/jimmunol.1402565

Berry, D., Kuzyk, O., Rauch, I., Heider, S., Schwab, C., Hainzl, E., Decker, T., Müller, M., Strobl, B., Schleper, C., Urich, T., Wagner, M., Kenner, L. & Loy, A. Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis. Front Microbiol 6, 1408 (2015). https://doi.org/10.3389/fmicb.2015.01408

Bauer, E., Witalisz, A., Strobl, B. & Stoiber, D. Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice. Methods Mol Biol 1267, 439-456 (2015). https://doi.org/10.1007/978-1-4939-2297-0_22

Vielnascher, R. M., Hainzl, E., Leitner, N. R., Rammerstorfer, M., Popp, D., Witalisz, A., Rom, R., Karaghiosoff, M., Kolbe, T., Müller, S., Rülicke, T., Lassnig, C., Strobl, B. & Müller, M. Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res 23, 519-529 (2014). https://doi.org/10.1007/s11248-014-9795-y

Strobl, B. & Moriggl, R. Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis. J Leukoc Biol 95, 849-851 (2014). https://doi.org/10.1189/jlb.0114051

Semper, C., Leitner, N. R., Lassnig, C., Parrini, M., Mahlakõiv, T., Rammerstorfer, M., Lorenz, K., Rigler, D., Müller, S., Kolbe, T., Vogl, C., Rülicke, T., Staeheli, P., Decker, T., Müller, M. & Strobl, B. STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity. Mol Cell Biol 34, 2235-2248 (2014). https://doi.org/10.1128/mcb.00295-14

Schwab, C., Berry, D., Rauch, I., Rennisch, I., Ramesmayer, J., Hainzl, E., Heider, S., Decker, T., Kenner, L., Müller, M., Strobl, B., Wagner, M., Schleper, C., Loy, A. & Urich, T. Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery. Isme j 8, 1101-1114 (2014). https://doi.org/10.1038/ismej.2013.223

Rauch, I., Hainzl, E., Rosebrock, F., Heider, S., Schwab, C., Berry, D., Stoiber, D., Wagner, M., Schleper, C., Loy, A., Urich, T., Müller, M., Strobl, B., Kenner, L. & Decker, T. Type I interferons have opposing effects during the emergence and recovery phases of colitis. Eur J Immunol 44, 2749-2760 (2014). https://doi.org/10.1002/eji.201344401

Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., Müller, M., Kalinke, U., Saeed, M., Chora, A. F., Golenbock, D. T., Strobl, B., Prudêncio, M., Coelho, L. P., Kappe, S. H., Superti-Furga, G., Pichlmair, A., Vigário, A. M., Rice, C. M., Fitzgerald, K. A., Barchet, W. & Mota, M. M. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20, 47-53 (2014). https://doi.org/10.1038/nm.3424

Leitner, N. R., Lassnig, C., Rom, R., Heider, S., Bago-Horvath, Z., Eferl, R., Müller, S., Kolbe, T., Kenner, L., Rülicke, T., Strobl, B. & Müller, M. Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo. PLoS One 9, e86608 (2014). https://doi.org/10.1371/journal.pone.0086608

Keil, E., Finkenstädt, D., Wufka, C., Trilling, M., Liebfried, P., Strobl, B., Müller, M. & Pfeffer, K. Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation. Blood 123, 520-529 (2014). https://doi.org/10.1182/blood-2013-03-492157

Gotthardt, D., Putz, E. M., Straka, E., Kudweis, P., Biaggio, M., Poli, V., Strobl, B., Müller, M. & Sexl, V. Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood 124, 2370-2379 (2014). https://doi.org/10.1182/blood-2014-03-564450

Bosmann, M., Strobl, B., Kichler, N., Rigler, D., Grailer, J. J., Pache, F., Murray, P. J., Müller, M. & Ward, P. A. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96, 123-131 (2014). https://doi.org/10.1189/jlb.3A1013-541R

Bosmann, M., Russkamp, N. F., Strobl, B., Roewe, J., Balouzian, L., Pache, F., Radsak, M. P., van Rooijen, N., Zetoune, F. S., Sarma, J. V., Núñez, G., Müller, M., Murray, P. J. & Ward, P. A. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol 193, 5668-5677 (2014). https://doi.org/10.4049/jimmunol.1302280

Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., Fuhrmann, V., Strobl, B., Müller, M., Schenk, P., Weiss, G. & Knapp, S. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 123, 3363-3372 (2013). https://doi.org/10.1172/jci67911

Bancerek, J., Poss, Z. C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Müller, M., Taatjes, D. J. & Kovarik, P. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity 38, 250-262 (2013). https://doi.org/10.1016/j.immuni.2012.10.017

Prchal-Murphy, M., Semper, C., Lassnig, C., Wallner, B., Gausterer, C., Teppner-Klymiuk, I., Kobolak, J., Müller, S., Kolbe, T., Karaghiosoff, M., Dinnyés, A., Rülicke, T., Leitner, N. R., Strobl, B. & Müller, M. TYK2 kinase activity is required for functional type I interferon responses in vivo. PLoS One 7, e39141 (2012). https://doi.org/10.1371/journal.pone.0039141

Mizutani, T., Neugebauer, N., Putz, E. M., Moritz, N., Simma, O., Zebedin-Brandl, E., Gotthardt, D., Warsch, W., Eckelhart, E., Kantner, H. P., Kalinke, U., Lienenklaus, S., Weiss, S., Strobl, B., Müller, M., Sexl, V. & Stoiber, D. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1, 1027-1037 (2012). https://doi.org/10.4161/onci.21284

Kernbauer, E., Maier, V., Stoiber, D., Strobl, B., Schneckenleithner, C., Sexl, V., Reichart, U., Reizis, B., Kalinke, U., Jamieson, A., Müller, M. & Decker, T. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 8, e1002763 (2012). https://doi.org/10.1371/journal.ppat.1002763

Derecka, M., Gornicka, A., Koralov, S. B., Szczepanek, K., Morgan, M., Raje, V., Sisler, J., Zhang, Q., Otero, D., Cichy, J., Rajewsky, K., Shimoda, K., Poli, V., Strobl, B., Pellegrini, S., Harris, T. E., Seale, P., Russell, A. P., McAinch, A. J., O'Brien, P. E., Keller, S. R., Croniger, C. M., Kordula, T. & Larner, A. C. Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab 16, 814-824 (2012). https://doi.org/10.1016/j.cmet.2012.11.005

Berry, D., Schwab, C., Milinovich, G., Reichert, J., Ben Mahfoudh, K., Decker, T., Engel, M., Hai, B., Hainzl, E., Heider, S., Kenner, L., Müller, M., Rauch, I., Strobl, B., Wagner, M., Schleper, C., Urich, T. & Loy, A. Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis. Isme j 6, 2091-2106 (2012). https://doi.org/10.1038/ismej.2012.39

Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amann, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Müller, M., Wagner, O., Patsch, W., Pospisilik, J. A. & Esterbauer, H. Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes 60, 1668-1676 (2011). https://doi.org/10.2337/db10-1628

Strobl, B., Stoiber, D., Sexl, V. & Mueller, M. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front Biosci (Landmark Ed) 16, 3214-3232 (2011). https://doi.org/10.2741/3908

Kropp, K. A., Robertson, K. A., Sing, G., Rodriguez-Martin, S., Blanc, M., Lacaze, P., Hassim, M. F., Khondoker, M. R., Busche, A., Dickinson, P., Forster, T., Strobl, B., Mueller, M., Jonjic, S., Angulo, A. & Ghazal, P. Reversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state. J Virol 85, 10286-10299 (2011). https://doi.org/10.1128/jvi.00373-11

Grunert, T., Leitner, N. R., Marchetti-Deschmann, M., Miller, I., Wallner, B., Radwan, M., Vogl, C., Kolbe, T., Kratky, D., Gemeiner, M., Allmaier, G., Müller, M. & Strobl, B. A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). J Proteomics 74, 2866-2880 (2011). https://doi.org/10.1016/j.jprot.2011.07.006

Blanc, M., Hsieh, W. Y., Robertson, K. A., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodríguez-Martín, S., Phelan, P., Forster, T., Strobl, B., Müller, M., Riemersma, R., Osborne, T., Wenk, M. R., Angulo, A. & Ghazal, P. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol 9, e1000598 (2011). https://doi.org/10.1371/journal.pbio.1000598

Vogl, C., Flatt, T., Fuhrmann, B., Hofmann, E., Wallner, B., Stiefvater, R., Kovarik, P., Strobl, B. & Müller, M. Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. BMC Genomics 11, 199 (2010). https://doi.org/10.1186/1471-2164-11-199

Radwan, M., Stiefvater, R., Grunert, T., Sharif, O., Miller, I., Marchetti-Deschmann, M., Allmaier, G., Gemeiner, M., Knapp, S., Kovarik, P., Müller, M. & Strobl, B. Tyrosine kinase 2 controls IL-1ß production at the translational level. J Immunol 185, 3544-3553 (2010). https://doi.org/10.4049/jimmunol.0904000

Hofmann, E., Reichart, U., Gausterer, C., Guelly, C., Meijer, D., Müller, M. & Strobl, B. Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses. BMC Cell Biol 11, 61 (2010). https://doi.org/10.1186/1471-2121-11-61

Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Müller, M., Blackshear, P. J., Poli, V., Lang, R., Murray, P. J. & Kovarik, P. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183, 1197-1206 (2009). https://doi.org/10.4049/jimmunol.0803883

Prchal, M., Pilz, A., Simma, O., Lingnau, K., von Gabain, A., Strobl, B., Müller, M. & Decker, T. Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity. Vaccine 27 Suppl 6, G17-20 (2009). https://doi.org/10.1016/j.vaccine.2009.10.016

Radwan, M., Miller, I., Grunert, T., Marchetti-Deschmann, M., Vogl, C., O'Donoghue, N., Dunn, M. J., Kolbe, T., Allmaier, G., Gemeiner, M., Müller, M. & Strobl, B. The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS). Proteomics 8, 3469-3485 (2008). https://doi.org/10.1002/pmic.200800260

Costantino, G., Egerbacher, M., Kolbe, T., Karaghiosoff, M., Strobl, B., Vogl, C., Helmreich, M. & Müller, M. Tyk2 and signal transducer and activator of transcription 1 contribute to intestinal I/R injury. Shock 29, 238-244 (2008). https://doi.org/10.1097/SHK.0b013e3180cab252

Miller, I., Radwan, M., Strobl, B., Müller, M. & Gemeiner, M. Contribution of cell culture additives to the two-dimensional protein patterns of mouse macrophages. Electrophoresis 27, 1626-1629 (2006). https://doi.org/10.1002/elps.200500744

Leitner, N. R., Strobl, B., Bokor, M., Painz, R., Kolbe, T., Rülicke, T., Müller, M. & Karaghiosoff, M. A time- and dose-dependent STAT1 expression system. BMC Biotechnol 6, 48 (2006). https://doi.org/10.1186/1472-6750-6-48

Strobl, B., Bubic, I., Bruns, U., Steinborn, R., Lajko, R., Kolbe, T., Karaghiosoff, M., Kalinke, U., Jonjic, S. & Müller, M. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175, 4000-4008 (2005). https://doi.org/10.4049/jimmunol.175.6.4000

Lassnig, C., Kolb, A., Strobl, B., Enjuanes, L. & Müller, M. Studying human pathogens in animal models: fine tuning the humanized mouse. Transgenic Res 14, 803-806 (2005). https://doi.org/10.1007/s11248-005-1676-y